IVOMEC 1% Injection produced significantly better efficacy than other endectocides in controlling faecal egg production.

50 calves were matched on faecal egg counts and randomly allocated among 5 groups. All calves received their allocated treatment on Day 0 and were then turned out to graze together as a single group for the entire study. Faecal samples were collected at weekly intervals from Day 21, and body weights were measured at the start and the finish of the study on Day 63.

• Group 1 was treated with oxfendazole orally at a dose of 4.5 mg/kg.
• Group 2 was treated with abamectin injection, subcutaneously at a dose of 200 mcg/kg.
• Group 3 was treated with moxidectin injection, subcutaneously at a dose of 200 mcg/kg.
• Group 4 was treated with doramectin injection, subcutaneously at a dose of 200 mcg/kg.
• Group 5 was treated with IVOMEC 1% Injection, subcutaneously at a dose of 200 mcg/kg.

On Days 49 and 56, cattle treated with IVOMEC had lower faecal egg counts than cattle in all the other groups and significantly lower counts than the oxfendazole group (Day 49 only) and the abamectin and moxidectin groups (P<0.05). The estimated total faecal egg output (cumulative faecal egg counts) of the group treated with IVOMEC was significantly lower than the total output of the oxfendazole group (82% reduction for IVOMEC; 45% reduction for the group treated with doramectin). The total egg output for the group treated with IVOMEC was also significantly lower than that of the abamectin and moxidectin groups. Larval cultures from bulk faecal samples from each group at each sampling showed that Cooperia and Ostertagia spp. predominated in all treatment groups on virtually all sampling dates. Although there were no significant body weight gain differences between groups (see figure), the greatest gain was observed in the group treated with IVOMEC.

Talty et al, 1998, Irish Vet J, 51:251-253

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